Objective: Compressive neuropathy is a common injury caused by trauma to the peripheral nerve, resulting in variable degrees of sensory and motor function impairments. The gold standard treatment involves complete surgical decompression of the affected area. However, surgical outcomes are unsatisfactory, with 10-25% of patients experiencing a recurrence of symptoms. Recent advancements in electrical stimulation have shown promise in augmenting nerve regeneration and rehabilitation. Though electrical stimulation has shown therapeutic benefits in controlling inflammation in various clinical fields, its effectiveness in peripheral nerve injury has not yet been established.
Material and Method: To validate the effectiveness of the unexplored nerve CCI model and analyze the regional immunomodulation influence on the peripheral nervous system, we applied the established protocol by the Tessa Gordon group. Result: Our results showed that brief electrical stimulation over injured peripheral nerves after nerve release can ameliorate neuropathic pain, enhance muscle regeneration, and improve action potential. The regulatory mechanism of electromodulation may be related to immunomodulatory regulation and M1/M2 transition.
Conclusion: Our study provides a comprehensive understanding of the neuromodulatory effect on compressive neuropathy, including the optimized stimulation dosage and underlying mechanism of immunomodulation. Additionally, our system-wide survey on the central nervous system, bone marrow niche, and hematologic activation will provide detailed information on systemic effects and toxicity, with significant implications for clinical translation.

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