Objective: This study aims to enhance diagnostic capabilities and treatment efficacy for Pyoderma Gangrenosum (PG), a rare autoimmune disease with an unknown etiology. By analyzing four cases from our hospital and reviewing relevant literature, we seek to improve patient outcomes and satisfaction while avoiding potentially harmful treatment approaches.

Materials and Methods: Utilizing our hospital's electronic records from May 2008 to December 2022, we identified four cases of PG. Each case's diagnosis, treatment, and disease progression are comprehensively detailed.

Results:
The first case involves a 61-year-old female with ulcerative colitis, showing improvement with steroid treatment after multiple surgical intervention.
In the second case, a 52-year-old female with rheumatoid arthritis required steroids after multiple surgical intervention, resulting in a non-healing wound.
The third case, a 66-year-old female with multiple conditions, successfully underwent debridement and antibiotic treatment for PG.
In the fourth case, a 54-year-old female with hypertension and diabetes experienced symptom relief with steroid cream following consultations.

Conclusions: PG, with an unknown etiology, often correlates with systemic diseases. Prolonged immunosuppressant use increases infection risks, necessitating consideration for patients with PG history and non-healing lesions. This research contributes valuable insights for individualized treatment strategies, emphasizing the importance of tailored approaches to enhance overall patient care and outcomes in PG management.