Keloids and hypertrophic scars are fibroproliferative disorders of the skin that result from abnormal healing of injured or irritated skin. Multiple studies suggest that genetic, systemic, and local factors may contribute to the development and/or growth of keloids and hypertrophic scars. Moreover, the severity of scarring is shaped by interactions between these local factors, genetic factors, and systemic factors such as hypertension and sex hormones. The Asian population is challenged with a high incidence of keloid occurrence with a specific genetic predominance. Nowadays burn related hypertrophic scar therapy included: surgery with Z-plasty, full-thickness skin graft (FTSG), compression therapy (compression garments), steroid injection, and laser treatment. Surgery with multiple Z-plasty is thought to have the most significant effect on decreasing recurrence rate. At present, I will present some preliminary reports revealed convincing evidence of feasibility and effectiveness of surgical treatment for burn and hypertrophic scar at Keelung Chang Gung Memorial Hospital.

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