Collagen is involved in all 3 phases of the wound healing cascade. Collagen-based materials stimulate and recruit specific cells, such as macrophages and fibroblasts, in order to enhance and influence wound healing. These biomaterials can provide moisture or absorption, depending on the delivery system. Collagen-based material were usually formulated with bovine, avian, or porcine collagen and were easy to apply on the wound.

This study was based on ALT free flap reconstruction for head and neck reconstruction. We divided the patient into two groups, intervention group (using HealiAId sheet at donor site in ALT free flap reconstruction) and control group (did not using HealiAId sheet). We compared overall complication (skin necrosis, hematoma/seroma, wound infection and wound dehiscence) rates, total drain amount, day to remove surgical drains, day to ambulation, and day to discharge.

The result revealed that there was no significant difference between two groups overall complications rates, day to ambulation and day to discharge. However, compared to control group, total drain amount and day to remove surgical drains were significantly lower in intervention group.