Chronic non-healing wound has become a major worldwide healthcare burden. The impact of biofilms on chronic wound infection is well-established. Despite increasing understanding of the underlying mechanism of biofilm formation in chronic wounds, current strategies for biofilm diagnosis and treatment in chronic wounds are still not ideal. Therefore, novel technologies are required to resolve this unmet clinical need.
We will summarize the current development of diagnostic tools of chronic wound biofilm infection in this talk. Despite a wide array of potential treatment options that are under development for biofilm-associated chronic wound infection, no reliable point-of-care diagnosis approach is currently available for the detecting biofilms. Eradicating biofilms is critical for the effective treatment of chronic non-healing infected wounds, and this procedure can be facilitated by timely and precise biofilm identification within the wound bed. For instance, wound blotting-guided sharp debridement can lead to more accurate removal of biofilm-affected wound area without collateral damage to the neighboring granulation tissue. With the advent of new diagnostic tools, timely biofilm assessment may become readily available and biofilm-directed clinical treatment can be issued whenever necessary. The continuous development of sophisticated diagnostic and treatment approaches can markedly contribute to future implementation of biofilm eradication in chronic wound.

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