Abstract
Lymphedema is a chronic, debilitating disease which affects as many as 200 million patients worldwide. In developed countries, cancer-related lymphedema is the most common secondary cause. Most studies have investigated the dysregulation of gene expressions focusing on regional adipose-tissue from breast cancer-related lymphedema. However, the systemic impacts of a localized lymphedema on have not been addressed.
First, from the bedside, the systemic effects of unilateral lower limb lymphedema will be investigated on the contralateral healthy limb. Second, moving from bedside to bench, lymphedema-related oxidative stress and dysregulated gene expression will be explored.

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