Skeletal muscle is the protein reservoir of our body and an important regulator of glucose and lipid homeostasis. Skeletal muscle atrophy is an important health issue and can impose tremendous economic burdens on healthcare systems. However, there is no effective way to combat muscle wasting.
Stem cell therapy is a form of regenerative medicine designed to repair damaged cells within the body by reducing inflammation and modulating the immune system. Adipose-derived stem cells (ASCs) represent an attractive and ethical cell source for stem cell therapy. Several ASC-derived paracrine factors are associated with their immunomodulatory effects. Systemic administration of ASCs can be a feasible option in various clinical circumstances and provides flexibility in terms of injection volume, dose and frequency.
Glucocorticoids (GCs) are one of well-known factors that result in muscle atrophy observed in numerous pathological conditions. Therefore, in our study, the development of effective therapeutic strategies for GC-induced muscle atrophy has clinical implications and with significant preliminary results.