Traditional physical therapy focuses primarily on rehabilitation, but recent developments in mechanobiology that illuminated the effects of physical forces on cells and tissues have led to the realization that the old therapy model should be updated. To achieve this, the term mechanotherapy is proposed. We show here how mechanobiology is recruited into mechanotherapy for the applications in the field of plastic surgery. The roles of mechanical forces in various techniques and therapies at the tissue level are demonstrated, including suturing, incision, fixation, topical glue, and tissue expansion for pathological scars; and vacuum assisted closure for wound repair; as well as mechanotherapies in organ reconstructions such as breast, ear/nose, and osteogenesis. Also, potential applications at cellular and molecular levels are illustrated. Hopefully, further research in mechanotherapy would generate a new era of viable and novel pharmacological and engineering interventions that help overcome human diseases.

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