Typically, wounds in mammals repair with scar tissue. This observation contributed to the dogma that fibrosis is the default outcome of wound healing and that fibroblasts are the pathogenic cell types during wound repair. However, the phenomenon of the so-called Wound-Induced Hair Neogenesis (WIHN), whereas large wounds in adult mice regenerate new hair follicles and new fat tissue, challenges this dogma. Upon WIHN, fibroblasts initially contribute to the formation of an early scar, but then are able to acquire new cell fates, such as dermal papilla cell and adipocyte identity. Recent works in our lab examined how WIHN is regulated at the single-cell level and with the help of biomaterials, and also studied evolutionary conservation of this phenomenon in salamanders, which are highly regenerative. This talk will discuss new progress in the lab on studying skin regeneration after injury.